STANLEY SAWYER
Research Interests

Research Interests:

Mathematical genetics, probability, statistics

Honors, Editorial Boards, Etc:

Fellow, Institute of Mathematical Statistics
Editorial Advisory Board, Molecular Biology and Evolution (2000-2008)
Associate Editor, Annals of Applied Probability (2006)
Deputy Editor for online publishing, Molecular Biology and Evolution (2000-2002)
Associate Editor, Molecular Biology and Evolution (1994-2000)
Probability Editor, Proceedings of the American Mathematical Society (1996-1999)
Associate Editor, Annals of Probability (1979-1985, 1991-1994)
NIH Genetics and GVE Study Sections, ad hoc (1991, 1998-2007)
NSF panels in probability and biology (2000, 2002)

Molecular Biology Computer Program
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Some Representative Recent Publications:

  • Amei, Amei, and Stanley A. Sawyer (2012) Statistical inference of selection and divergence from a time-dependent poisson random field model. PLoS ONE 7 (4), doi:10.1371/journal.pone.0034413

  • Leopold, Shana R., Stanley A. Sawyer, Thomas S. Whittam, and Phillip I. Tarr (2011) Obscured phylogeny and recombinational dormancy in Escherichia coli. BMC Evolutionary Biology 11, 183.

  • Amei, Amei, and Stanley A. Sawyer (2010) A time-dependent Poisson random field model for polymorphism within and between two related biological species. Annals of Applied Probability 20, 1663--1696.

  • Leopold Shana R, Magrini V, ..., Mardis Elaine R, ..., Sawyer Stanley A, Whittam Thomas S, and Tarr Phillip I (2009) A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis. Proceedings of the National Academy of Sciences USA Vol.106, 8713-8718.

  • Sawyer, Stanley A, John Parsch, Zhi Zyhang, and Daniel L Hartl (2007) Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila. Proceedings of the National Academy of Sciences USA Vol.104, 6504-6510.

    Background   How can one tell in which direction evolution is going? (A nontechnical description of the motivation behind the previous paper. This was written for the Web site of someone who was nice enough to provide access to a microprocessor array when I was on sabbatical in 2002.)

  • Butler, Marguerite, Stanley A. Sawyer, and Jonathan Losos (2007) Sexual dimorphism is an agent for increased morphological diversity in an adaptive radiation. Nature Vol.447, May 10 issue, 202-205.

  • Fauquet, C. M., S. Sawyer, A. M. Idris, and J. K. Brown (2005) Sequence analysis and classification of apparent recombinant begomoviruses infecting tomato in the Nile and Mediterranean Basins. Phytopathology Vol.95, 549-555.

  • Volkman, Sarah K., Elena Lozovsky, Alyssa E. Barry, Trevor Bedford, Lara Bethke, Alissa Myrick, Karen P. Day, Daniel L. Hartl, Dyann F. Wirth, and Stanley A. Sawyer (2007) Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene Vol.387, 1-6.

  • Piccirillo, Jay F., Edward L. Spitznagel, Anna Vlahiotis, and S. A. Sawyer (2006) Development of Prognostigram: A cancer patient-specific prognostic program. (Survival curves influenced by high blood pressure, other diseases, etc.) Manuscript.

  • Sawyer, S A, R J Kulathinal, C D Bustamante, and D L Hartl (2003) Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection. Journal of Molecular Evolution 57, S154-S164. PDF file

    Talk (PDF file)

  • Bustamante, C D, R Nielsen, S A Sawyer, K M Olsen, M D Purugganan, and D L Hartl (2002) The cost of inbreeding in Arabidopsis. Nature 416, pp531-534. PDF file

  • Rich, S M, S A Sawyer, and A G Barbour (2001) Antigen polymorphism in Borrelia hermsii, a clonal pathogenic bacterium. Proceedings of the National Academy of Sciences USA 98, pp15038-15043.

  • Bustamante, C D, J Wakeley, S A Sawyer, and D L Hartl (2001) Directional selection and the site-frequency spectrum. Genetics 159, pp1779-1788.

  • Hartl, D L, E F Boyd, C D Bustamente, and S A Sawyer (2000) The glean machine: What can we learn from DNA sequence polymorphisms? In S. Suhai (Ed.), Genomics and proteomics, Kluwer Academic / Plenum Publishers, New York, pp37-49.

  • Padidam, M, S A Sawyer, and C Fauquet (1999) Possible emergence of new geminiviruses by frequent recombination. Virology 265, pp218-225.

  • S A Sawyer (1997) Estimating selection and mutation rates from a random field model for polymorphic sites. In P. Donnelly and S. Tavare (Eds.), Progress in population genetics and human evolution, IMA Volumes in Mathematics and its Applications 87, Springer-Verlag, New York, 1997, pp193-206. PDF file

  • S A Sawyer (1997) Martin boundaries and random walks. In Adam Koranyi (Ed.), Harmonic functions on trees and buildings. Contemporary Mathematics 206, American Mathematical Society, Providence, pp17-44. PDF file

    Some Older Publications:

  • Kapur, V, S Kanjilal, M R Hamrick, L-L Li, T S Whitham, S A Sawyer, and J M Musser (1995) Molecular population genetic analysis of the streptokinase gene of Streptococcus pyogenes: mosaic alleles generated by recombination. Molecular Microbiology 16, pp509-519.

  • S A Sawyer (1994) Inferring selection and mutation from DNA sequences: The McDonald-Kreitman test revisited. In G. B. Golding (Ed.) Non-Neutral Evolution: Theories and Molecular Data. Chapman and Hall, 1994, pp77-87. PDF file

  • Hartl, D L, Etsuko Moriyama, and S A Sawyer (1994) Selection intensity for codon bias. Genetics 138, pp227-234.

  • Phillips, O, Alwyn Gentry, P Hall, S A Sawyer, and R. Vasquez (1994) Dynamics and species-richness of tropical rain forests. Proceedings of the National Academy of Sciences USA 91, pp2805-2809.

  • Sawyer, S A, and D L Hartl (1992) Population genetics of polymorphism and divergence. Genetics 132, pp1161-1176. PDF file

  • Palazzolo, M, S A Sawyer, C Martin, D Smoller, and D. L. Hartl (1991) Optimized strategies for sequence-tagged-site selection in genome mapping. Proceedings of the National Academy of Sciences of the USA 88 (1991), pp8034-8038.

  • Sawyer, S A (1990) Maximum likelihood estimators for incorrect models, with an application to ascertainment bias for continuous characters. Theoretical Population Biology 38, pp351-366.

  • Sawyer, S A (1989) Statistical tests for detecting gene conversion. Molecular Biology and Evolution 6, pp526-538. PDF file

  • Sawyer, S A, D E Dykhuizen, R DuBose, L Green, T Mutangadura-Mhlanga, D Wolczyk, and D. L. Hartl (1987) Distribution and abundance of insertion sequences among natural isolates of Escherichia coli. Genetics 115, pp51-63.

    Some Older Publications Yet:

  • Sawyer, S A (1979) A limit theorem for patch sizes in a selectively-neutral migration model. Jour. Applied Probability 16, pp482-495.

  • Sawyer, S A, and J Fleischman (1979) Maximum geographic range of a mutant allele considered as a sub-type of a Brownian branching random field. Proceedings of the National Academy of Sciences USA 76, pp872-875.

  • Sawyer, S A (1976) Branching diffusion processes in population genetics. Adv. Applied Probability 8, pp659-689.

  • Sawyer, S A (1977) On the past history of an allele now known to have frequency p. Jour. Applied Probability 14, pp439-450.

  • Sawyer, S A (1974) A Fatou theorem for the general one-dimensional parabolic equation. Indiana Univ. Math. Jour. 24, 451-498.

    Books:

    A TeX Primer for Scientists, Stanley Sawyer and Steven Krantz,
    CRC Press, Boca Raton, FL (1995, 399+viii pgs.)
    For more information:
    Amazon.com On-Line Books | CRC Press

    Click here to email: sawyer@math.wustl.edu

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    Last modified August 11, 2013