Professor Chengjie Xiong
 

Division of Biostatistics, Washington University, School of Medicine
 

Title: Meta-analyses when individual patient data are only partly available
 

Abstract: Systematic reviews have become increasingly used as a means of assessing and interpreting the results from biomedical research. Whereas statistical methods for meta-analysis using either summary statistics or individual patient data across all studies have been well developed, especially in the area of controlled clinical trials, little attention has been paid to the case when individual patient data are only available for part of the studies and summary statistics have to be used for the rest of the studies in the meta-analysis. We propose a likelihood based approach for meta-analyses when individual patient data are only partly available. The proposed methodology can also be used when an original study is carried out in which the individual patient data from the current research can be integrated through a meta-analysis with at least summary statistics from already existing published studies to address the same scientific questions.